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Common Name: PCK This model of polycystic kidney disease showing both kidney and liver involvement was identified in a colony of CD rats from the Charles River Japan production facility. The identification of the Pkhd1 gene mutation was reported in 2000. This autosomal recessive Pkhd1 gene mutation is a model of human autosomal recessive polycystic kidney disease (ARPKD). To Charles River (CRUS) in 2006. Re-introduced to Charles River Laboratories Japan, Inc. [predecessor of The Jackson Laboratory Japan, Inc.] in 2012.
Polycystic kidney disease, autosomal recessive trait(ARPKD)1) 1)Makoto KATSUYAMA et al. 2000, Exp Anim 49(1) 51-55
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